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Streeterville is a neighborhood in the Near North Side community area of Chicago, Illinois, United States, north of the Chicago River in Cook County. It is bounded by the river on the south, the Magnificent Mile portion of Michigan Avenue on the west, and Lake Michigan on the north and east. Thus, it can be described as the Magnificent Mile plus all land east of it. The majority of the land in this neighborhood is reclaimed landfill and sandbar.

The neighborhood contains a combination of hotels, restaurants, professional office centers, residential high rises, universities, medical facilities, and cultural venues. The area has undergone increased development in the early 21st century as numerous empty lots in Streeterville have been converted into commercial and residential properties, especially in the southern part of the neighborhood. The neighborhood had earlier experienced booms following World War I and World War II.

Transportation in the South Loop is a snap, with access to Metra, the El Blue, Red, Green and Orange Lines, and CTA buses on many major streets. The South Loop also has I-90 on its western edge and I-41 along the lakeshore.

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